Standard book references for AIIMS, AIPGMEE and DNB
Harrison’s Principles of Internal Medicine has a been the most important one text book of choice of examiners and successful candidates for Indian Medical PG exam preparation for the past 10 years. This trend continues and the the new Harrison’s Principles of Internal Medicine 19th Preview Edition features many new chapters and topics which are likely to be of interest for the examiners. The value of Harrison’s 19th Edition for Medical PG Preparation is unquestionable considering the major content increase in this edition.
What can you expect from Chemoprevention of cancers for AIIMS and AIPGMEE?
Which of the following is effective in reducing mortality in lung cancer?
C. Isotretinoin (13-cis-retinoic acid)
D. None of the above
This is an interesting question because most studies have failed to prove that any of these agents could reduce mortality in Lung CA. The two important studies to remember are (ATBC) and Lung Cancer Prevention Trial and Retinol Efficacy Trial (CARET).
α-tocopherol: Is found to have no effect on Lung cancer. There was increased incidence of haemorrhagic stroke.
β-carotene: Is found to increase mortality in lung cancer in smokers.
Isotretinoin (13-cis-retinoic acid): Is found to increase mortality in lung cancer in smokers. Chemotherapy with high/ toxic doses of Isotretinoin causes regression of leukoplakia.
Which of the following are TRUE about smoking cessation?
A. Reduces the risk of a second malignancy of Aerodigestive tract
B. Reduces the risk of malignancy in people who never had cancer
C. Halts the later stages of the carcinogenic process
D. All of the above are true
A. Reduces the risk of a second malignancy of Aerodigestive tract. FALSE. Smoking cessation does not reduce the second malignancy developing in the upper aerodigestive tract in patients cured of squamous cell cancers.
B. It does reduce the risk of malignancy in people who never had cancer. TRUE
C. Halts the later stages of the carcinogenic process. False. Smoking cessation halts the early stages on carcinogenesis. E.g. metaplasia
Ref: Croswell JM, Brawley OW, Kramer BS. Prevention and Early Detection of Cancer.In: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds.Harrison’s Principles of Internal Medicine, 19e. New York, NY: McGraw-Hill; 2014. http://accessmedicine.mhmedical.com/content.aspx?bookid=1130&Sectionid=69857455
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