FREE AIIMS MCQ on 29 Oct 2016

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 DAILY FREE MCQ CHALLENGE for Medical PG Preparation

Question
Which among the following is a calcineurin inhibitor?

A. Leflunomide
B. Cyclosporine
C. Methotrexate
D. Mycophenolate mofetil

TIPSImportant Question from AIIMS 2013

Answer: B. Cyclosporine

Explanation :

 

Cyclosporine, Tacrolimus are calcineurin inhibitors.

Cyclosporine

Cyclosporine is an immunosuppressive agent with efficacy in human organ transplantation, in the treatment of graft-versus-host (GVH) disease.

Mechanism of action

  • Cyclosporine is a peptide antibiotic that appears to act at an early stage in the antigen receptor-induced differentiation of T cells and blocks their activation.
  • Cyclosporine binds to cyclophilin, a member of a class of intracellular proteins called immunophilins.
  • Cyclosporine and cyclophilin form a complex that inhibits the cytoplasmic phosphatase, calcineurin, which is necessary for the activation of a T-cell-specific transcription factor.
Reference: Immunopharmacology. In: Katzung BG, Trevor AJ. eds. Basic & Clinical Pharmacology, 13e. Reference link


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