FREE AIIMS MCQ on 02 Nov 2016

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 DAILY FREE MCQ CHALLENGE for Medical PG Preparation

Question
What is Etanercept?

A. COX 2 inhibitor
B. IL 6 inhibitor
C. TNF inhibitor
D. IFN gamma inhibitor

TIPSImportant Question from AIIMS 2013

Answer: C. TNF inhibitor

Explanation :

Etanercept

  • Etanercept (Enbrel) is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human TNF receptor linked to the Fc portion of human IgG1.
  • Etanercept binds selectively to TNF-α and -β and blocks interaction with cell surface TNF receptors that play a role in the inflammatory process of plaque psoriasis.
  • The recommended dosage of etanercept in psoriasis is a 50 mg subcutaneous injection given twice weekly for 3 months followed by a maintenance dose of 50 mg weekly.
Reference: Dermatologic Pharmacology. In: Katzung BG, Trevor AJ. eds. Basic & Clinical Pharmacology, 13e. Reference link


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